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Typical neurovascular complications of Ehlers-Danlos syndrome are carotid- cavernous fistulae,intracranial aneurysms,and cervical artery dissections. Arterial dissections and intracranial aneurysms cause the majority of neurovascular symptoms in Marfan's syndrome.Neurovascular disease is uncommon in osteogenesis imperfecta,although carotid-cavernous fistulae and vertebral artery dissections have been reported.Neurovascular disease in pseudoxanthoma elasticum is characterized by intracranial aneurysms and cerebral ischemia caused by premature arterial occlusive disease. Intracranial occlusive arterial disease is the most common neurovascular manifestation of neurofibromatosis,followed by cervical arteriovenous fistulae and aneurysms and intracranial aneurysms.Intracranial aneurysms are the hallmark of polycystic kidney disease.Recognition of an underlying generalized connective tissue disorder may be of considerable importance, although marked phenotypic heterogeneity often complicates the diagnosis of these disorders.Conversely,the association of certain neurovascular anomalies with generalized connective tissue disorders and recognition of their basic molecular defect may offer clues to the etiology and pathogenesis of these neurovascular diseases in general. |
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aneurysm
aneurysm,intracranial
arterial dissection
arterial dissection,carotid
arterial dissection,ruptured
arterial dissection,vertebral
cerebral ischemia
cerebrovascular accident
cerebrovascular accident,familial occurrence
cerebrovascular accident,non atherosclerotic cause of
cerebrovascular disease
collagen vascular disease
Ehlers-Danlos syndrome
epidemiology of neurology
familial
fistula,arterio-venous
fistula,arterio-venous,carotid-cavernous
genetic neurologic disorders
Marfan syndrome
osteogenesis imperfecta
pseudoxanthoma elasticum
review article
skin,lesions in neurologic disorders
subarachnoid hemorrhage
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